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[99mTc]Tc-N4-[Hse7]MJ9

Development stage: Preclinical
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

[99mTc]Tc-N4-[Hse7]MJ9 is a technetium-99m labeled radiopharmaceutical designed for SPECT/CT imaging of tumors expressing the gastrin-releasing peptide receptor (GRPR). It consists of a modified bombesin derivative (MJ9) where the glutamine at position 7 is replaced with homoserine (Hse7), conjugated to an N4 chelator (6-carboxy-1,4,8,11-tetraazaundecane). This modification aims to optimize pharmacokinetics by improving tumor-to-background contrast in the abdominal region and reducing radiation dose to the pancreas, which naturally expresses GRPR. Preclinical studies in PC-3 prostate cancer models have demonstrated high receptor affinity and favorable biodistribution.

Other names: 99mTc-N4-[Hse7]MJ9technetium-99m N4-[Hse7]MJ9

Targets

GRPR (Gastrin-releasing peptide receptor)

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